| Ray Palmer Baker Distinguished Professorship (1997) | Toh-Ming Lu |
| Richard Baruch M.D. Career Development Professor (2006) | (vacant) |
| Clay P. Bedford, Sr. ‘24 Endowed Chair Professorship (2003) | (vacant) |
| Howard N. Blitman ‘50 P.E. Career Development Professor in Engineering (2004) | Satish Ukkusuri |
| Irene and Robert Bozzone ‘55 Assistant Professor of Management and Technology (1995) | (vacant) |
| Ann and John H. Broadbent Jr. ‘59 Senior Constellation Professor, Biocatalysis and Metabolic Engineering (2003) | Robert J. Linhardt |
| Warren H. Bruggeman ‘46 and Pauline Urban Bruggeman Distinguished Associate Professor (1995) | (vacant) |
| Henry Burlage Chaired Professor in Engineering (2005) | Robert Hull |
| Dorothy and Fred Chau ‘71 Career Development Constellation Professor in Biocatalysis and Metabolic Engineering (2007) | (vacant) |
| Constellation Professor, Biocomputation and Bioinformatics (2005) | Angel E. Garcia |
| Constellation Professor, Biocomputation and Bioinformatics (2007) | George Makhatadze |
| Constellation Professor, Future Chips (2004) | Shawn-Yu Lin |
| Constellation Professor, Tetherless World (2006) | James A. Hendler |
Constellation Professor, Tetherless World (2007) Constellation Professor, Tetherless World (2008) | Deborah L. McGuinness Peter Fox |
| John A. Clark and Edward T. Crossan Professor of Engineering (1974) | (vacant) |
| Thomas and Constance D’Ambra Professor in Synthetic Organic Chemistry (2006) | (vacant) |
| David M. Darrin ‘40 Senior Endowed Chair at the Darrin Fresh Water Institute (2006) | (vacant) |
| Margaret A. Darrin Distinguished Professor in Applied Mathematics (1981) | (vacant) |
| James L. Decker ‘45 Endowed Chair in Aerospace Engineering (2007) | (vacant) |
| Amos Eaton Professor of Computer Science (1991) | (vacant) |
| Ford Foundation Professor of Mathematics (1967) | Joyce R. McLaughlin |
| Frank and Lillian Gilbreth Professor in the Technologies of Management (1969) | Albert S. Paulson |
| Alma and H. Erwin Hale ‘30 Teaching Professorship of Humanities and Social Sciences (1991) | Linda L. Layne |
Edward P. Hamilton Distinguished Educator (1975) Edward P. Hamilton Distinguished Professor of Science Education (2009) | Joseph G. Ecker Frank Spear |
| William Howard Hart Professor of Rational and Technical Mechanics (1883) | (vacant) |
| Edward E. Hood Jr. Professorship (1989) | (vacant) |
| John Tod Horton ‘52 Professor of Materials Engineering (1971) | David Duquette |
| Robert W. Hunt Professor of Materials Science and Engineering (1938) | Richard W. Siegel |
| Institute Professor (1994) | (vacant) |
| Institute Professor of Engineering (1991) | Ricardo Dobry |
| Institute Professor of Nuclear Engineering (1981) | (vacant) |
| Institute Professor of Science (1995) | E. Bruce Watson |
| Institute Professor of Science (1988) | (vacant) |
| Institute Professor of Science and Technology (1983) | (vacant) |
| Howard P. Isermann ‘42 Professor of Chemical and Biological Engineering (1989) | Jonathan Dordick |
| Samuel A. Johnson ‘37 and Elisabeth C. Johnson Professor in Engineering (1990) | Mark S. Shephard |
| J. Erik Jonsson ‘22 Distinguished Professor (1997) | Xi-Cheng Zhang |
| Kodak Associate Professor in Environmental Engineering (1991) | (vacant) |
| Gail and Jeffrey L. Kodosky ‘70 Chair in Physics, Information Technology, and Entrepreurship | Shengbai Zhang |
| Gail and Jeffrey L. Kodosky ‘70 Career Development Chair | (vacant) |
| Frederic R. Kolleck ‘52 Career Development Professor in Chemistry (2008) | (vacant) |
| Louis Ellsworth Laflin Professor of English (1917) | Merrill D. Whitburn |
| P.K. Lashmet Career Development Chair (2008) | Ravi Kane |
| Ruth and Augustine Marusi ‘36 Professorship in Global Business Management (2006) | Jonathan Story |
| Elaine S. and Jack S. Parker Chair in Engineering | Shekhar Garde |
| Thomas Phelan Chair in Humanities and Social Sciences (1995) | Langdon Winner |
| Rayleigh Chair for Theoretical Physics (1962) | (vacant) |
| Rosalind and John J. Redfern Jr. ‘33 Professor of Engineering (1981) | Jacob Fish |
| Eliza Ricketts Foundation Professor of Mathematics (1937) | Donald A. Drew |
| Virginia and Lloyd W. Rittenhouse ‘35 Teaching Professor of Humanities and Social Sciences (2004) | John M. Gowdy |
| Patricia W. and C. Sheldon Roberts ‘48 Chaired Professor in Solid State Electronics (1991) | Michael S. Shur |
| Russell Sage Professor of Chemical and Biological Engineering (1938) | Georges Belfort |
| Claire and Roland Schmitt Distinguished Professorship (2007) | Boleslaw Szymanski |
| Alan Paul Schulz Career Development Professor of Chemistry (2004) | (vacant) |
Philip Sporn Professor of Electric Power Engineering (1962) Travelstead Institute Chair | (vacant) Gwo-Ching Wang |
| William Weightman Walker Professor of Chemistry (1905) | Linda McGown |
| William Weightman Walker Professor of Polymer Engineering (1905) | Steven Cramer |
| Wellfleet Career Development Constellation Professor, Future Chips (2004) | Christian M. Wetzel |
| Wellfleet Senior Constellation Professor, Future Chips (2003) | E. Fred Schubert |
| Cary L. Wellington Professor of Management of Technology (1988) | Iftekhar Hasan |
| Dean R. Wellington ‘83 Teaching Professorship in Management (1990) | (vacant) |
| Yamada Corporation Professor (2001) | (vacant) |